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胞质DNA感受器 (CDS) 激动剂及相关产品推荐

2022-05-06
浏览次数: 232

CDS可识别受损的、定位错误的、或致病性DNA,进而通过TBK1-IRF3通路诱导I型干扰素的产生。DNA通常定位于细胞核或线粒体中,但当它的合成或运输出现错误时会在细胞浆中聚集。此外,在感染情况下,病毒或微生物的DNA也可以进入到宿主细胞的细胞浆中。许多CDS已经被报道,包括腺苷脱氨酶DAI、解旋酶DDX41、干扰素诱导的IF116蛋白,以及cGAS(环-GMP-AMP合成酶)。AIM2是另外一种胞浆脱氧核糖核酸传感器,它受到刺激后形成炎症小体并进一步诱导产生IL-1®。


相关产品推荐:

PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

CDS Agonists

ODN TTAGGG (A151)

Inhibitory ODN, human preferred

TLR2 -/ TLR4 -

100 nM - 10 µM

200 µg

1 mg

tlrl-ttag151

tlrl-ttag151-1

dsDNA-EC

E. coli K12 genomic DNA

TLR2 -/ TLR4 -

30 ng - 1 µg/ml

200 µg

tlrl-ecdna

G3-YSD                                      NEW

Y-form DNA

TLR2 -/ TLR4 -

100 ng - 1 µg/ml

200 µg

tlrl-ydna

G3-YSD Control                   NEW

Control for Y-form DNA

TLR2 -/ TLR4 -

100 ng - 1 µg/ml

200 µg

tlrl-ydnac

HSV-60 Naked

HSV1-derived 60 bp oligonucleotide

TLR2 -/ TLR4 -

30 ng - 10 µg/ml

200 µg

tlrl-hsv60n

HSV-60 LyoVec

Precomplexed HSV1-derived 60 bp ODN

TLR2 -/ TLR4 -

300 ng - 10 µg/ml

100 µg

tlrl-hsv60c

HSV-60c Naked

Control for HSV-60 ODN

TLR2 -/ TLR4 -

30 ng - 10 µg/ml

200 µg

tlrl-hsv60cn

HSV-60c/LyoVec

Precomplexed control for HSV-60 ODN

TLR2 -/ TLR4 -

300 ng - 10 µg/ml

100 µg

tlrl-hsv60cc

ISD Naked

Interferon stimulatory DNA

TLR2 -/ TLR4 -

100 ng - 10 µg/ml

200 µg

tlrl-isdn

ISD/LyoVec

Precomplexed interferon stimulatory DNA

TLR2 -/ TLR4 -

300 ng - 10 µg/ml

100 µg

tlrl-isdc

ISD Control Naked

Non-immunostimulatory ODN

TLR2 -/ TLR4 -

100 ng - 10 µg/ml

200 µg

tlrl-isdcn

ISD Control/LyoVec

Precomplexed non-immunostimulatory ODN

TLR2 -/ TLR4 -

300 ng - 10 µg/ml

100 µg

tlrl-isdcc

Poly(dA:dT) Naked

Poly(dA-dT)poly(dT-dA)

TLR2 -/ TLR4 -

1 - 5 µg/ml

200 µg

1 mg

tlrl-patn

tlrl-patn-1

Poly(dA:dT)/LyoVec

Poly(dA-dT)poly(dT-dA)/LyoVec complexes

TLR2 -/ TLR4 -

1 - 5 µg/ml

100 µg

tlrl-patc

Poly(dA:dT)/Rhodamine

Rhodamine labeled poly(dA-dT)poly(dT-dA)

TLR2 -/ TLR4 -

30 ng - 10 µg/ml

10 µg

tlrl-patrh

Poly(dG:dC) Naked

Poly(dG-dC)poly(dG-dC)

TLR2 -/ TLR4 -

10 ng - 10 µg/ml

200 µg

tlrl-pgcn

Poly(dG:dC)/LyoVec

Poly(dG-dC)poly(dG-dC)/LyoVec complexes

TLR2 -/ TLR4 -

10 ng - 10 µg/ml

100 µg

tlrl-pgcc

VACV-70 Naked

Vaccinia virus-derived 70 bp oligonucleotide

TLR2 -/ TLR4 -

30 ng - 10 µg/ml

200 µg

tlrl-vav70n

VACV-70/LyoVec

Precomplexed vaccinia virus-derived 70 bp ODN

TLR2 -/ TLR4 -

300 ng - 10 µg/ml

100 µg

tlrl-vav70c

VACV-70c Naked

Control for VACV-70 ODN

TLR2 -/ TLR4 -

30 ng - 10 µg/ml

200 µg

tlrl-vav70cn

VACV-70c/LyoVec

Precomplexed control for VACV-70 ODN

TLR2 -/ TLR4 -

300 ng - 10 µg/ml

100 µg

tlrl-vav70cc

如需订购以上产品或咨询其它技术/产品详情问题,请联系Invivogen一级代理商欣博盛生物


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