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sting激动剂及相关产品推荐

2022-05-07
浏览次数: 174

STING分子在最初发现时只被认为是CDS信号通路中的一个普通接头蛋白,进一步研究表明它是环二核苷酸cyclic dinucleotide(CDNs)的直接感受分子。CDNs是细菌合成的重要第二信使,调节原核生物及哺乳动物的众多生物进程,能启动宿主天然免疫反应。CDNs和山酮衍生物xanthenone derivative(例如DMXAA),可结合并活化STING,通过TBK1-IRF3依赖的信号通路来诱导I型干扰素表达。


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PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

STING Agonists

22-cGAMP

25-25 Cyclic GMP-AMP

TLR2 -/ TLR4 -

100 ng - 100 µg/ml

500 µg

1 mg

tlrl-nacga22

tlrl-nacga22-1

23-cGAMP

25-35 Cyclic GMP-AMP

TLR2 -/ TLR4 -

100 ng - 100 µg/ml

200 µg

500 µg

1 mg

5 mg

tlrl-ncga23-02 tlrl-nacga23

tlrl-nacga23-1

tlrl-nacga23-5

23-cGAMP Control

Linear dinucleotide analog of 23-cGAMP

TLR2 -/ TLR4 -

100 ng - 100 µg/ml

1 mg

tlrl-nagpap

23-cGAMP VacciGrade  

Preclinical grade 25-35 cyclic GMP-AMP

VacciGrade

5 - 50 µg/mouse

1 mg

vac-nacga23

23-cGAM(PS)2 (Rp/Sp)

Bis-phosphorothioate analog of 23-cGAMP

TLR2 -/ TLR4 -

100 ng - 100 µg/ml

250 µg

tlrl-nacga2srs

23-c-di-AMP

Synthetic analog of  c-di-AMP

TLR2 -/ TLR4 -

1 - 100 µg/ml

500 µg

tlrl-nacda23

23-c-di-AM(PS)2 (Rp,Rp)

Bisphosphorothioate analog of 23-c-di-AMP

TLR2 -/ TLR4 -

0.1-10 µg/ml

100 µg

500 µg

tlrl-nada2r-01

tlrl-nacda2r

23-c-di-AM(PS)2 (Rp,Rp) VacciGrade

Preclinical grade of bisphosphorothioate analog of
2
3-c-di-AMP

VacciGrade

5-50 µg/mouse

500 µg

vac-nacda2r

23-c-di-GMP

Synthetic analog of c-di-GMP

TLR2 -/ TLR4 -

1 - 100 µg/ml

500 µg

tlrl-nacdg23

33-cGAMP

35-35 Cyclic GMP-AMP

TLR2 -/ TLR4 -

100 ng - 100 µg/ml

500 µg

1 mg

5 x 0.5 mg

tlrl-nacga

tlrl-nacga-1

tlrl-nacga-2.5

33-cGAMP Control

Linear dinucleotide analog of 33-cGAMP

TLR2 -/ TLR4 -

100 ng - 100 µg/ml

1 mg

tlrl-nagpap

33-cGAMP Fluorinated

Difluor cyclic [G(3,5)pA(3,5)p]

TLR2 -/ TLR4 -

100 ng - 10 µg/ml

100 µg

tlrl-nacgaf

cAIMP (CL592)

Cyclic [A(3,5)pI(3,5)p]

TLR2 -/ TLR4 -

300 ng - 30 µg/ml

500 µg

tlrl-nacai

cAIMP Difluor (CL614)

Difluor cyclic [A(3,5)pI(3,5)p]

TLR2 -/ TLR4 -

100 ng - 30 µg/ml

250 µg

tlrl-nacaidf

cAIM(PS)2 Difluor (Rp/Sp)

Difluor and bisphosphorothioate analog of cAIMP

TLR2 -/ TLR4 -

100 ng - 30 µg/ml

100 µg

tlrl-nacairs

c-di-AMP

35 Cyclic di-AMP

TLR2 -/ TLR4 -

1 - 100 µg/ml

1 mg

5 x 1 mg

tlrl-nacda

tlrl-nacda-5

c-di-AMP Control

Linear dinucleotide analog of c-di-AMP - pApA

TLR2 -/ TLR4 -

1 - 100 µg/ml

1 mg

tlrl-napapa

c-di-AMP VacciGrade

Sterile 35 cyclic di-AMP

VacciGrade

5 - 50 µg/mouse

1 mg

vac-nacda

c-di-AMP Fluorinated

Difluoro [A(3,5)pA(3,5)p]

TLR2 -/ TLR4 -

300 ng - 30 µg/ml

100 µg

tlrl-nacdaf

c-di-GMP

35 Cyclic di-GMP

TLR2 -/ TLR4 -

10 - 100 µg/ml

1 mg

5 x 1 mg

tlrl-nacdg

tlrl-nacdg-5

c-di-GMP Control

Linear dinucleotide 5-pGpG; negative control for c-di-GMP

TLR2 -/ TLR4 -

10 - 100 µg/ml

1 mg

tlrl-napgpg

c-di-GMP VacciGrade

Preclinical grade of cyclic [G(3,5)pG(3,5)p]

VacciGrade

5 - 50 µg/mouse

1 mg

tlrl-nacdg

c-di-GMP Fluorinated

Difluoro cyclic [G(3,5)pG(3,5)p]

TLR2 -/ TLR4 -

3 - 100 µg/ml

100 µg

tlrl-nacdgf

c-di-IMP

Cyclic [I(3,5)pI(3,5)p]

TLR2 -/ TLR4 -

10 - 100 µg/ml

1 mg

tlrl-nacdi

c-di-UMP

Negative control for c-di-IMP

TLR2 -/ TLR4 -

1 - 100 µg/ml

1 mg

tlrl-nacdu

DMXAA

5,6-dimethyl-xanthenone-4-acetic acid

TLR2 -/ TLR4 -

10 - 100 µg/ml

5 mg

tlrl-dmx

如需购买或咨询以上产品详情,请联系Invivogen一级代理商-欣博盛生物


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