您好,欢迎光临欣博盛生物科技商城!
服务热线:400 680 0892
新闻资讯 News

Epicypher热销产品——SMARCA2 Chromatin Remodeling Enzyme (Human BRM)

2023-10-23
浏览次数: 15


 

EpiCypher是一家为表观遗传学和染色质生物学研究提供高质量试剂和工具的专业制造商。EpiCypher能提供全长重组人SMARCA4染色质重塑酶。SMARCA4是ATP依赖性染色质重塑复合物SWI/SNF的核心ATP酶亚基,可动员核小体,在基因转录调控、发育、基因组复制和修复中发挥关键作用[1,2]。SWI/SNF亚基的异常活性与超过20%的人类癌症和多种发育障碍相关,这使得SMARCA2成为一个新兴的候选治疗靶点[3,4]。SMARCA4可用于结合EpiDyne®-FRET Remodeling Assay Substrate (EpiCypher 16-4201)在HTS兼容药物发现研究。

[1] Clapier & Carins Annu. Rev. Biochem. (2009). PMID: 19355820

[2] Sundaramoorthy & Owen-Hughes F1000Research (2020). PMID: 32864100

[3] Kadoch & Crabtree Sci. Adv. (2015). PMID: 26601204

[4] Cenik & Shilatifard Cells (2022). PMID: 32958894


产品详情

宿主来源: Human

表达系统: SF9 cells

保存温度: Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.

运输温度: Dry ice.

产品形式: SMARCA4 at 0.15 mg/mL in 12.5 µL of 25 mM HEPES pH 7.6, 0.1 mM EDTA, 10% glycerol, 350 mM NaCl, 1 mM DTT, 0.4 mM PMSF, 1 mM benzamidine, 0.02% NP-40, 0.4 mg/mL insulin.


验证数据


Epicypher热销产品——SMARCA2 Chromatin Remodeling Enzyme (Human BRM)

Figure 1: ATP-dependent chromatin remodeling assay

EpiDyne®-FRET Chromatin Remodeling Substrate (EpiCypher 16-4201; 20nM) incubated with SMARCA4 Remodeling Enzyme (concentrations indicated) in 1x SMARCA Remodeling Assay Buffer. Curves denote FRET efficiency/chromatin remodeling.



Epicypher热销产品——SMARCA2 Chromatin Remodeling Enzyme (Human BRM)

Figure 2: Protein gel data

SMARCA4 Remodeling Enzyme (1 µg) was run on an SDS-PAGE gel and stained with Coomassie blue. The migration and molecular weight of the protein standards are indicated.



订购详情

货号

产品名称

规格

15-1014

SMARCA4 Chromatin Remodeling Enzyme (Human BRG1)

100 Reactions


 

Epicypher热销产品——CUTANA™ pAG-Tn5 for CUT&Tag

如需了解更多详细信息或相关产品,请联系EpiCypher中国授权代理商-欣博盛生物 

全国服务热线: 4006-800-892       邮箱: market@neobioscience.com 

深圳: 0755-26755892         北京: 010-88594029            

广州:020-87615159           上海: 021-34613729

代理品牌网站: www.neobioscience.com 

自主品牌网站: www.neobioscience.n


分享到:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
  网站地图
犀牛云提供企业云服务