您好,欢迎光临欣博盛生物科技商城!
服务热线:400 680 0892
新闻资讯 News

BioXCell热销产品--RecombiMAb anti-mouse CSF1R (CD115)

2023-09-01
浏览次数: 50

BioXCell热销产品--RecombiMAb anti-mouse CSF1R (CD115)

 

产品描述:

AFS98-CP131单克隆抗体是原始AFS98单克隆抗体的重组嵌合型抗体。可变结构域序列与原始AFS98单克隆抗体相同,但是恒定区序列已经从大鼠IgG2a变到小鼠IgG2a。AFS98-CP131单克隆抗体像原始大鼠IgG2a抗体一样,不包含Fc突变。

 

AFS98-CP131单克隆抗体能与小鼠集落刺激因子1受体(CSF1R),也称为巨噬细胞集落刺激因子受体(M-CSFR),即CD115反应。CSF1R是一种单程I型膜蛋白,是血小板衍生生长因子受体家族的成员。在小鼠中,CSF1R由单核细胞/巨噬细胞、腹膜渗出物细胞、浆细胞样和常规树突细胞以及破骨细胞表达。CSF1R是CSF1的受体,CSF1通过CSF1R调节单核细胞谱系中细胞的增殖和分化。据报道,AFS98单克隆抗体可在体内deplete巨噬细胞并阻断CSFR1。

BioXCell热销产品--RecombiMAb anti-mouse CSF1R (CD115)

 

产品详情:

产品名称

RecombiMAb anti-mouse CSF1R (CD115)

产品货号

CP131

产品规格

1/5/25/50/100mg

反应种属

Mouse

克隆号

AFS98-CP131

同种型

Mouse IgG2a(switched from rat IgG2a)

免疫原

Not available or unknown

实验应用

in vivo macrophage depletion*
in vitro CSF1R neutralization*
in vivo monocyte depletion*
Flow cytometry*
Western blot*
*Reported for the original rat IgG2a AFS98 antibody

产品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

纯度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

无菌处理

0.2 µm filtration

纯化方式

Protein A

分子量

150 kDa

小鼠病原检测

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存条件

抗体原液保存在4°C,不能冷冻保存。

推荐同型对照

InVivoPlus mouse IgG2a isotype control, unknown specificity(货号BP0085)

推荐抗体稀释液

InVivoPure pH 7.0 Dilution Buffer(货号IP0070)

 

 

该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:

应用

文章

体内巨噬细胞耗竭

(in vivo macrophage 

depletion)

1. Bauche, D., et al. (2018). 'LAG3(+) Regulatory T Cells Restrain Interleukin-23-Producing 

CX3CR1(+) Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis' 

Immunity 49(2): 342-352 e345.

2. Gordon, S. R., et al. (2017). 'PD-1 expression by tumour-associated macrophages inhibits 

phagocytosis and tumour immunity' Nature 545(7655): 495-499.

3. Moynihan, K. D., et al. (2016). 'Eradication of large established tumors in mice by combination 

immunotherapy that engages innate and adaptive immune responses' Nat Med. doi : 10.1038/nm.4200.

4. Naik, S., et al. (2015). 'Commensal-dendritic-cell interaction specifies a unique protective 

skin immune signature' Nature 520(7545): 104-108.

体外CSF-R1中和

(in vitro CSF-R1 

neutralization)

1.Sheng, K. C., et al. (2014). 'IL-3 and CSF-1 interact to promote generation of 

CD11c+IL-10-producing macrophages' PLoS One 9(4): e95208. 

流式细胞术

(Flow Cytometry)

1. Li, W., et al. (2012). 'Intravital 2-photon imaging of leukocyte trafficking in beating 

heart' J Clin Invest 122(7): 2499-2508. 

2. Tagliani, E., et al. (2011). 'Coordinate regulation of tissue macrophage and dendritic 

cell population dynamics by CSF-1' J Exp Med 208(9): 1901-1916.

 

 

BioXCell热销产品--RecombiMAb anti-mouse CSF1R (CD115)

更多产品详情请咨询 BioXCell 中国授权代理——欣博盛生物

全国服务热线: 4006-800-892       邮箱: market@neobioscience.com 

深圳: 0755-26755892         北京: 010-88594029            

广州:020-87615159           上海: 021-34613729

代理品牌网站: www.neobioscience.com 

自主品牌网站: www.neobioscience.net

分享到:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
  网站地图
犀牛云提供企业云服务