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BioXcell热销产品--InVivoPlus anti-mouse CD8α

2023-04-27
浏览次数: 45

BioXcell热销产品--InVivoPlus anti-mouse CD8α

 

产品描述:

BioXcell InVivoPlus anti-mouse CD8α克隆号YTS 169.4单克隆抗体能与小鼠CD8α反应。CD8抗原是一种跨膜糖蛋白,作为T细胞受体的共受体。与TCR一样,CD8与抗原呈递细胞(APC)展示的I类MHC分子结合。CD8主要在细胞毒性T细胞表面表达,但也可在胸腺细胞、自然杀伤细胞和一些树突状细胞亚群中发现。CD8最常见的存在形式是由一个CD8α和一个CD8β链组成的异二聚体,然而,它也可以是由两个CD8α链组成的同二聚体。CD8α和CD8β链均与免疫球蛋白可变轻链具有显著同源性。每个CD8链的分子量约为34 kDa。BioXcell InVivoPlus anti-mouse CD8α克隆号YTS 169.4抗体在体内使用时显示出depleting活性。


BioXcell热销产品--InVivoPlus anti-mouse CD8α 

产品详情:


产品名称

InVivoPlus anti-mouse CD8α

产品货号

BP0117

产品规格

5/25/50/100mg

反应种属

Mouse

克隆号

YTS 169.4

同种型

Rat IgG2b, κ

免疫原

CBA mouse thymocytes

实验应用

in vivo CD8+ T cell depletion
Western blot

产品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

纯度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

无菌处理

0.2 µm filtration

纯化方式

Protein G

RRID

AB_10950145

分子量

150 kDa

小鼠病原检测

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存条件

抗体原液保存在4°C,不能冷冻保存。

推荐同型对照

InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin(货号BP0090)

推荐抗体稀释液

InVivoPure pH 7.0 Dilution Buffer(货号IP0070)



为什么选择InVivoPlus抗体?

InVivoPlus级别的产品内毒素含量更低,经过多种实验验证,更适合用于体内实验研究

BioXcell热销产品--InVivoPlus anti-mouse CD8α


 该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:


应用

文章

体内CD8+T细胞耗竭

(in vivo CD8+ T cell depletion)

1. Vashist, N., et al. (2018). 'Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression' Front Immunol 9: 505.

2. Triplett, T. A., et al. (2018). 'Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' Nat Biotechnol 36(8): 758-764.

3. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity' Nature 521(7550): 99-104.

4. Burrack, K. S., et al. (2015). 'Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells' PLoS Pathog 11(10): e1005191.

5. Wensveen, F. M., et al. (2015). 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance' Nat Immunol 16(4): 376-385.

6. Li, Z., et al. (2015). 'Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' Transpl Immunol 33(2): 125-129.

 

 

BioXcell热销产品--InVivoPlus anti-mouse CD8α

更多产品详情请咨询 BioXcell 中国授权代理——欣博盛生物

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