您好,欢迎光临欣博盛生物科技商城!
服务热线:400 680 0892
新闻资讯 News

TLR7/8 激动剂及相关产品

2022-04-21
浏览次数: 291

TLR7和TLR8都是与病毒感染引起的免疫反应相关的胞内受体。它们识别富含GU的短单链RNA,以及咪唑喹啉和核苷类似物等人工合成的小分子。TLR7/TLR8的信号通路依赖于MyD-88的活化、AP-1和IFN-α/β等转录因子入核,以及IRF7的磷酸化。IRF7磷酸化诱导ISRE的表达和I型干扰素基因的产生,而AP-1和IFN-α/β的激活导致细胞因子的释放。


TLR7/8 激动剂相关产品:


PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR7 Agonists

CL264

Adenine analog

TLR2 - /TLR4 -

50 ng - 10 µg/ml

500 µg

5 mg

tlrl-c264e

tlrl-c264e-5

CL307

Hydroxyadenine spermine compound

TLR2 - /TLR4 -

5 ng - 1 µg/ml

500 µg

tlrl-c307

CL347 - AdiFectin

Hydroxyadenine spermine compound

TLR2 - /TLR4 -

300 ng - 3 µg/ml

500 µg

tlrl-c347

CL401

PAM2C-conjugated hydroxyadenine compound

TLR2 + /TLR4 -

1 ng - 10 µg/ml

500 µg

tlrl-c401

CL401 VacciGrade

Preclinical grade CL401

VacciGrade

20 - 50 µg/mouse

1 mg

vac-c401-5

CL413 - Adilipoline

PAM2CK4-conjugated hydroxyadenine compound

TLR2 + /TLR4 -

50 pg - 10 µg/ml

500 µg

tlrl-c413

TLR7 Agonists

CL413 VacciGrade

Preclinical grade CL413

VacciGrade

20 - 50 µg/mouse

5 mg

vac-c413-5

CL531

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

5 pg - 10 µg/ml

500 µg

tlrl-c531

CL572

Monoacyl-ethyl-cystein hydroxyadenine compound

TLR2 +/ TLR4 -

0.5 ng - 1 µg/ml

500 µg

tlrl-c572

Gardiquimod

Imidazoquinoline compound

TLR2 -/ TLR4 -

0.1 - 3 µg/ml

500 µg

5 mg

tlrl-gdqs

tlrl-gdq-5

Imiquimod (R837)

Imidazoquinoline compound

TLR2 -/ TLR4 -

1 - 5 µg/ml

500 µg

5 mg

tlrl-imqs

tlrl-imq

Imiquimod  VacciGrade

Preclinical grade Imiquimod

TLR2 -/ TLR4 -

10 - 100 µg/mouse

5 mg

vac-imq

Loxoribine

Guanosine analog

TLR2 -/ TLR4 -

1 mM (300 µg/ml)

50 mg

tlrl-lox

TLR8 Agonists

ORN06/LyoVec

ssRNA with 6 UUGU repeats / LyoVec

TLR2 -/ TLR4 -

0.25 - 5 µg/ml

4 x 25 µg

tlrl-orn6

ssPolyU Naked

RNA homopolymer

TLR2 -/ TLR4 -

1 - 10 µg/ml

10 mg

10  x 10 mg

tlrl-sspu

tlrl-sspu-100

ssPolyU/LyoVec

RNA homopolymer / LyoVec

TLR2 -/ TLR4 -

1 - 10 µg/ml

4 x 25 µg

tlrl-lpu

ssRNA40/LyoVec

HIV-1 LTR-derived ssRNA / LyoVec

TLR2 -/ TLR4 -

0.25 - 5 µg/ml

4 x 25 µg

tlrl-lrna40

ssRNA41/LyoVec

ssRNA40 control / LyoVec

TLR2 -/ TLR4 -

0.25 - 5 µg/ml

4 x 25 µg

tlrl-lrna41

TL8-506

Benzoazepine analog

TLR2 -/ TLR4 -

10 - 100 ng/ml

500 µg

tlrl-tl8506

TLR7/8 Agonists

CL075

Thiazoquinoline compound

TLR2 -/ TLR4 -

100 ng - 5 µg/ml

500 µg

5 mg

tlrl-c75

tlrl-c75-5

CL097

Imidazoquinoline compound

TLR2 -/ TLR4 -

50 ng - 5 µg/ml

500 µg

5 mg

tlrl-c97

tlrl-c97-5

Poly(dT)

Thymidine homopolymer ODN (17 mer)

TLR2 -/ TLR4 -

10 µM

100 nmol

tlrl-pt17

R848 (resiquimod)

Imidazoquinoline compound

TLR2 -/ TLR4 -

10 ng - 10 µg/ml

500 µg

5 mg

tlrl-r848

tlrl-r848-5

R848 VacciGrade

Preclinical grade R848

VacciGrade

10 - 100 µg/mouse

5 mg

vac-r848


更多详情请咨询Invivogen一级代理商-欣博盛生物


全国服务热线: 4006-800-892  邮箱: market@neobioscience.com 

深圳: 0755-26755892      北京: 010-88594029      上海: 021-34613729           

广州:020-87615159        香港: 852-69410778 

代理品牌网站: www.neobioscience.com 

自主品牌网站: www.neobioscience.net

分享到:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳欣博盛生物科技有限公司
  网站地图
犀牛云提供企业云服务