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TLR4 激动剂及相关产品介绍

2022-04-12
浏览次数: 453

TLR4是革兰氏阴性菌脂多糖(LPS)和毒性成份lipid A的受体。TLR4与LPS的应答,除了受体本身,也需要另外3种不同的胞外蛋白:LBP(LPS结合蛋白)、CD14和MD-2(髓样分化蛋白2)才能发挥作用。TLR4介导的信号通路有两条:一条是MyD88依赖 的,另一条是MyD88非依赖的。MyD88依赖的信号通路导致AP-1和NF-kB等转录因子入核,促进一些炎症因子的释放;MyD88非依赖的信号通路可激活IRF3和另外一个接头分子TRAM(TRIF相关的接头蛋白),IRF3活化后可使细胞产生IFN-®️,上调一些干扰素依赖基因的表达。


TLR4激动剂相关产品:


PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR4 Agonists

CRX-527            NEW         

Synthetic Lipid A analog

TLR2 - /TLR4 +

100 pg/ml - 10 ng/ml

1 mg

tlrl-crx527

LPS-B5

Standard lipopolysaccharide from E. coli 055:B5

TLR2 + /TLR4 +

100 pg - 1 µg/ml

5 mg

tlrl-b5lps

LPS-B5 Ultrapure

Ultrapure lipopolysaccharide from E. coli 055:B5

TLR2 - /TLR4 +

100 pg - 1 µg/ml

5 mg

tlrl-pb5lps

LPS-EB

Standard lipopolysaccharide from E. coli 0111:B4

TLR2 + /TLR4 +

10 ng - 10 µg/ml

5 mg

tlrl-eblps

LPS-EB Biotin

Biotinylated ultrapure LPS from E. coli 0111:B4

TLR2 + /TLR4 +

10 ng - 10 µg/ml

500 µg

tlrl-3blps

LPS-EB Ultrapure

Ultrapure lipopolysaccharide from E. coli 0111:B4

TLR2 - /TLR4 +

10 ng - 10 µg/ml

5x106 EU

tlrl-3pelps

LPS-EB VacciGrade

Preclinical grade ultrapure LPS from E. coli 0111:B4

VacciGrade

0.1 - 25 µg/mouse

5x106 EU

vac-3pelps

LPS-EK

Standard lipopolysaccharide from E. coli K12

TLR2 + /TLR4 +

1 ng - 10 µg/ml

5 mg

tlrl-eklps

LPS-EK Ultrapure

Ultrapure lipopolysaccharide from E. coli K12

TLR2 - /TLR4 +

1 ng - 10 µg/ml

1 mg

tlrl-peklps

LPS-PG

Standard lipopolysaccharide from P. gingivalis

TLR2 + /TLR4 +

100 ng - 10 µg/ml

1 mg

tlrl-pglps

LPS-PG Ultrapure

Ultrapure lipopolysaccharide from P. gingivalis

TLR2 - /TLR4 +

100 ng - 10 µg/ml

1 mg

tlrl-ppglps

LPS-SM Ultrapure

Ultrapure lipopolysaccharide from S. minnesota

TLR2 - /TLR4 +

10 ng - 10 µg/ml

5 mg

tlrl-smlps

MPLA-SM

Monophosphoryl lipid A from S. minnesota

TLR2 - /TLR4 +

10 ng - 1 µg/ml

1 mg

tlrl-mpla

MPLA-SM VacciGrade

Preclinical grade detoxified MPLA

VacciGrade

2 - 20 µg/mouse

1 mg

vac-mpla

MPLA Synthetic

Synthetic monophosphoryl lipid A

TLR2 - /TLR4 +

300 pg - 100 ng/ml

1 mg

tlrl-mpls

MPLA Synthetic VacciGrade

Preclinical grade synthetic MPLA

VacciGrade

2 - 20 µg/mouse

1 mg

vac-mpls

TLR4 Antagonist

LPS-RS

Lipopolysaccharide from Rhodobacter sphaeroides

TLR2 + /TLR4 -

10 ng - 10 µg/ml

5 mg

tlrl-rslps

LPS-RS Ultrapure

Ultrapure lipopolysaccharide from R. sphaeroides

TLR2 - /TLR4 -

10 ng - 10 µg/ml

1 mg

tlrl-prslps


更多详情请咨询Invivogen一级代理商-欣博盛生物


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