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TLR2激动剂(又名CD282)及相关产品介绍

2022-04-12
浏览次数: 4240

TLR2(又名CD282)是一个可以识别多种微生物表面分子的细胞膜表面受体。它识别的分子可来源于革兰氏阳性菌、革兰氏阴性菌、支原体和酵母等许多微生物种属。


TLR2识别的具体成份包括来源于革兰氏阳性菌的肽聚糖、脂膜酸、脂蛋白,来源于分枝杆菌的脂阿拉伯甘露聚糖,来源于酵母细胞壁的酵母聚糖等。


TLR2识别的配体种类在TLR家族中是最多的,因为TLR2可以和其它TLR家族成员形成异源二聚体来发挥功能。


TLR2可以和TLR6形成异源二聚体识别双酰化脂蛋白,而TLR1/TLR2异源二聚体则与三酰化脂蛋白发生相互作用。


另外,CD14共受体的存在可增强TLR2的病原识别能力。TLR2信号通路的激活依赖于MyD88分子(骨髓来源的第一应激蛋白88),进而招募接头分子TIRAP(TIR相关蛋白),导致AP-1和NF-kB等转录因子入核来促进一些炎症因子的释放。


TLR2激动剂相关产品:


PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

TLR LIGANDS

TLR2 Agonists

CL401

PAM2C-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

1 ng - 10 µg/ml

500 µg

tlrl-c401

CL401 VacciGrade

Preclinical grade CL401

VacciGrade

20 - 50 µg/mouse

5 mg

vac-c401-5

CL413 - Adilipoline

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

50 pg - 10 µg/ml

500 µg

tlrl-c413

CL413 VacciGrade

Preclinical grade CL413

VacciGrade

20 - 50 µg/mouse

5 mg

vac-c413-5

CL419

Pam2C-spermine compound

TLR2 +/ TLR4 -

1 ng - 100 µg/ml

500 µg

tlrl-c419

CL429

Pam2C-conjugated murabutide

TLR2 +/ TLR4 -

1 ng - 10 µg/ml

5 mg

tlrl-c429

CL429 VacciGrade

Preclinical grade CL429

VacciGrade

20 - 50 µg/mouse

5 mg

vac-c429

CL531

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

5 pg - 10 µg/ml

500 µg

tlrl-c531

CL572

Monoacyl-ethyl-cystein hydroxyadenine compound

TLR2 +/ TLR4 -

0.5 ng - 1 µg/ml

500 µg

tlrl-c572

FSL-1

Synthetic diacylated lipoprotein - TLR2/6

TLR2 +/ TLR4 -

1 - 100 ng/ml

100 µg

tlrl-fsl

HKBF

Heat Killed Bacteroides fragilis

TLR2 +/ TLR4 -

106 - 107 cells/m

109 cells

tlrl-hkbf

HKEB

Heat Killed Escherichia coli 0111:B4

TLR2 +/ TLR4 +

105 - 107 cells/ml

1010 cells

tlrl-hkeb

HKLM

Heat Killed Listeria monocytogenes

TLR2 +/ TLR4 -

107 - 108 cells/ml

1010 cells

tlrl-hklm

HKLR

Heat Killed Lactobacillus rhamnosus

TLR2 +/ TLR4 -

108 - 109 cells/ml

1010 cells

tlrl-hklr

HKMT

Heat Killed Mycobacterium tuberculosis

TLR2 +/ TLR4 -

100 ng - 10 µg/ml

10 mg

50 mg

tlrl-hkmt-1

tlrl-hkmt-5

HKPA

Heat Killed Pseudomonas aeruginosa

TLR2 +/ TLR4 -

105 - 107 cells/ml

1010 cells

tlrl-hkpa

HKSA

Heat Killed Staphylococcus aureus

TLR2 +/ TLR4 -

106 - 108 cells/ml

1010 cells

tlrl-hksa

HKSE

Heat Killed Staphylococcus epidermidis

TLR2 +/ TLR4 -

107 - 109 cells/ml

1010 cells

tlrl-hkse

HKSP

Heat Killed Streptococcus pneumoniae

TLR2 +/ TLR4 -

107 - 109 cells/ml

1010 cells

tlrl-hksp

HKST

Heat Killed Salmonella typhimurium

TLR2 +/ TLR4 +

104 - 109 cells/ml

1010 cells

tlrl-hkst

LPS-PG

Standard Lipopolysaccharide from P. gingivalis

TLR2 +/ TLR4 +

10 ng - 10 mg/ml

1 mg

tlrl-pglps

LTA-BS

Lipoteichoic acid from Bacillus subtilis

TLR2 +/ TLR4 +

100 ng - 1 µg/ml

5 mg

tlrl-lta

LTA-SA

Lipoteichoic acid from S. aureus

TLR2 +/ TLR4 +

100 ng - 1 µg/ml

5 mg

tlrl-slta

LTA-SA Purified

Purified lipoteichoic acid from S. aureus

TLR2 +/ TLR4 -

1 ng - 1 µg/ml

5 mg

tlrl-pslta

Pam2CSK4

Synthetic diacylated lipoprotein - TLR2(6)

TLR2 +/ TLR4 -

1 - 100 ng/ml

1 mg

tlrl-pm2s-1

Pam3CSK4

Synthetic triacylated lipoprotein - TLR1/2

TLR2 +/ TLR4 -

1 - 300 ng/ml

1 mg

tlrl-pms

Pam3CSK4 Biotin

Biotinylated Pam3CSK4

TLR2 +/ TLR4 -

10 - 300 ng/ml

50 µg

tlrl-bpms

Pam3CSK4 Rhodamine

Rhodamine-labeled Pam3CSK4

TLR2 +/ TLR4 -

1 - 300 ng/ml

50 µg

tlrl-rpms

Pam3CSK4 VacciGrade

Preclinical grade Pam3CSK4

VacciGrade

2 - 20 µg/mouse

1 mg

vac-pms

PGN-BS

Peptidoglycan from B. subtilis

TLR2 +/ TLR4 -

1 - 10 µg/ml

5 mg

tlrl-pgnb3

PGN-EB

Peptidoglycan from E. coli 0111:B4

TLR2 +/ TLR4 +

1 - 10 µg/ml

1 mg

tlrl-pgneb

PGN-EK

Peptidoglycan from E. coli K12

TLR2 +/ TLR4 +

1 - 10 µg/ml

1 mg

tlrl-pgnek

PGN-SA

Peptidoglycan from S. aureus

TLR2 +/ TLR4 -

0.1 - 10 µg/ml

5 mg

tlrl-pgns2

Zymosan

Cell wall preparation of S. cerevisiae

TLR2 +/ TLR4 -

1-10 µg/ml

100 mg

tlrl-zyn


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