微环境中的代谢变化显著调节肿瘤免疫敏感性,但其潜在机制仍不清楚。最近,清华大学生命科学学院团队在期刊《Cell Metabolism》(IF=31.373)上发表题为“Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment.”的文章,报道了富马酸水合酶(FH)缺失的肿瘤表现出对功能性CD8+ T细胞活化、扩增和功效的抑制,并具有增强的恶性增殖能力。推断肿瘤细胞中的FH缺失会在肿瘤间质液中积累延胡索酸,增加的延胡索酸可直接在C96和C102处琥珀酸化ZAP70,并减弱其在浸润CD8+ T细胞中的活性,导致CD8+ T细胞活化受到抑制,并在体外和体内产生抗肿瘤免疫反应。此外,通过增加FH表达来消除延胡索酸盐可显著增强抗CD19 CAR T细胞的抗肿瘤功效。该研究证明了富马酸在控制TCR信号中的作用,并表明肿瘤微环境(TME)中的富马酸积累是CD8+ T细胞抗肿瘤功能的代谢障碍。该研提出了延胡索酸的减少可能是肿瘤免疫治疗的一个重要策略。
本文中使用了欣博盛Human Granzyme B ELISA kit检测了细胞培养上清中这个细胞因子的含量。
1.文章题目:Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment.
期 刊:Cell Metabolism(影响因子:31.373)
发表时间:12 May 2023
作 者:Cheng J, Yan J, Liu Y, et al.
作者单位:清华大学生命科学学院
使用产品:Human Granzyme B ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37178684/
2.文章题目:Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease.
期 刊:Cell Host & Microbe(影响因子:31.316)
发表时间:15 May 2023
作 者:Liang W, Yang Y, Gong S, et al.
作者单位:华南师范大学
使用产品:Mouse IgA, IgG, IgM and Human IgA, IgG, IgM ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37207649/
3.文章题目:Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation.
期 刊:Nature Communications(影响因子:17.694)
发表时间:23 May 2023
作 者:Wang K, Li Y, Wang X, et al.
作者单位:沈阳药科大学
使用产品:Mouse CXCL10, IFN-β, IL-12p70 and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37221157/
4.文章题目:Gastric Acid‐Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora.
期 刊:Advanced Science(影响因子:17.521)
发表时间:1 May 2023
作 者:Yu J, Guo Z, Yan J, et al.
作者单位:中山大学
使用产品:Mouse IL-1β, IL-6, and TNF-α ELISA kits
样本类型:胃组织
https://pubmed.ncbi.nlm.nih.gov/37127895/
5.文章题目:Enhanced tissue infiltration and bone regeneration through spatiotemporal delivery of bioactive factors from polyelectrolytes modified biomimetic scaffold.
期 刊:Materials Today Bio(影响因子:10.761)
发表时间:24 May 2023
作 者:Zhou X, Wang Z, Li T, et al.
作者单位:东华大学
使用产品:Human BMP-2 ELISA kit
https://www.sciencedirect.com/science/article/pii/S2590006423001412
6.文章题目:Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity.
期 刊:Environmental Pollution(影响因子:9.988)
发表时间:12 May 2023
作 者:Cui M, He Q, Wang Z, et al.
作者单位:中山大学
使用产品:Mouse IL-10 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37182580/
7.文章题目:Recombinant Treponema pallidum Protein Tp47 Promoted the Phagocytosis of Macrophages by Activating NLRP3 Inflammasome Induced by PKM2‐Dependent Glycolysis.
期 刊:Journal of the European Academy of Dermatology and Venereology(影响因子:9.228)
发表时间:29 May 2023
作 者:Zheng Y W, Wang M, Xie J W, et al.
作者单位:厦门大学
使用产品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37247195/
8.文章题目:Exploiting Broad-Spectrum Chimeric Lysin to Cooperate with Mupirocin against Staphylococcus aureus-Induced Skin Infections and Delay the Development of Mupirocin Resistance.
期 刊:Microbiology Spectrum(影响因子:9.043)
发表时间:1 May 2023
作 者:Duan X, Li X, Li X, et al.
作者单位:华中农业大学
使用产品:Mouse TNF-α and IL-6 ELISA kits
样本类型:皮肤组织
https://pubmed.ncbi.nlm.nih.gov/37125939/
9.文章题目:Butyrate mitigates metabolic dysfunctions via the ERα-AMPK pathway in muscle in OVX mice with diet-induced obesity.
期 刊:Cell Communication and Signaling(影响因子:7.525)
发表时间:4 May 2023
作 者:Fu Q, Li T, Zhang C, et al.
作者单位:山东大学齐鲁医学院
使用产品:Human insulin ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37143096/
文章题目:Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice.
期 刊:Biomedicine & Pharmacotherapy(影响因子:7.419)
发表时间:9 May 2023
作 者:Wei X, Xin J, Chen W, et al.
作者单位:武汉大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
样本类型:大脑皮质和结肠组织均匀
https://pubmed.ncbi.nlm.nih.gov/36442338/
11.文章题目:Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases.
期 刊:Acta Pharmacologica Sinica(影响因子:7.169)
发表时间:24 May 2023
作 者:Xiong F, Zhang W, Zheng C, et al.
作者单位:中国科学院上海药物研究所
使用产品:Mouse IL12/23p40 and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37225846/
12.文章题目:Diversity-oriented synthesis of diterpenoid alkaloids yields a potent anti-inflammatory agent.
期 刊:Phytomedicine(影响因子:6.656)
发表时间:29 May 2023
作 者:Li X, Zhang J, Chen Q, et al.
作者单位:四川大学华西医院
使用产品:Mouse IL-6 and TNF-α ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0944711323002684
13.文章题目:Maternal supplementation of human milk derived Lactiplantibacillus plantarum WLPL04 affects the immunity and gut microbiota of offspring rats.
期 刊:Food & Function(影响因子:6.317)
发表时间:9 May 2023
作 者:Zhong C, Wang Q, He Y, et al.
作者单位:南昌大学
使用产品:Rat IFN-γ, TNF-α, IL-2, IL-4, IL-6, and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37204244/
14.文章题目:Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo.
期 刊:Marine Drugs(影响因子:6.085)
发表时间:17 May 2023
作 者:Wang L, Oliveira C, Li Q, et al.
作者单位:五邑大学
使用产品:Mouse IL-10 ELISA kit
https://www.mdpi.com/1660-3397/21/5/302
15.文章题目:Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells.
期 刊:Frontiers in Pharmacology(影响因子:5.988)
发表时间:20 May 2023
作 者:Yang X F, Liu X, Yan X Y, et al.
作者单位:辽宁师范大学
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37021059/
16.文章题目:Evaluation of humoral and cellular immune responses induced by a cocktail of recombinant African swine fever virus antigens fused with OprI in domestic pigs.
期 刊:Virology Journal(影响因子:5.913)
发表时间:26 May 2023
作 者:Zhang G, Liu W, Yang S, et al.
作者单位:中国农业科学院兰州兽医研究所
使用产品:Mouse TNF-α and IL-12p70 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37237390/
17.文章题目:Clinical characteristics and host immunity responses of SARS-CoV-2 Omicron variant BA. 2 with deletion of ORF7a, ORF7b and ORF8.
期 刊:Virology Journal(影响因子:5.913)
发表时间:29 May 2023
作 者:Tang Z, Yu P, Guo Q, et al.
作者单位:茂名市人民医院
使用产品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37248496/
18.文章题目:Intracellular Polysaccharides of Aspergillus cristatus from Fuzhuan Brick Tea Leverage the Gut Microbiota and Repair the Intestinal Barrier to Ameliorate DSS-Induced Colitis in Mice.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:18 May 2023
作 者:Xie Z, Zeng Z, Chen G, et al.
作者单位:南京农业大学
使用产品:Mouse TNF-α, IL-1β, IFN-γ and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37203140/
19.文章题目:IgE Recognition and Structural Analysis of Disulfide Bond Rearrangement and Chemical Modifications in Allergen Aggregations in Roasted Peanuts.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:31 May 2023
作 者:Zhang Y, Song M, Xu J, et al.
作者单位:南昌大学
使用产品:山羊抗兔IgG(H+L)-HRP
https://pubmed.ncbi.nlm.nih.gov/37256970/
20.文章题目:Heat-Killed Bifidobacterium longum BBMN68 in Pasteurized Yogurt Alleviates Mugwort Pollen-Induced Allergic Airway Responses through Gut Microbiota Modulation in a Murine Model.
期 刊:Foods(影响因子:5.561)
发表时间:19 May 2023
作 者:Niu X, Yin X, Wu X, et al.
作者单位:中国农业大学
使用产品:Mouse IgE, IgG, IL-4, IL-5, IL-13, IFN-γ, and IL-17 ELISA kits
https://www.mdpi.com/2304-8158/12/10/2049
21.文章题目:Therapeutic effect of the total saponin from Panax Japonicus on experimental autoimmune encephalomyelitis by attenuating inflammation and regulating gut microbiota in mice.
期 刊:Journal of Ethnopharmacology(影响因子:5.195)
发表时间:23 May 2023
作 者:Wang J, He L, Wang S, et al.
作者单位:首都医科大学
使用产品:Mouse IL-1β, IL-6, and TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37230280/
22.文章题目:Blood unconjugated bilirubin and tacrolimus are negative predictors of specific cellular immunity in kidney transplant recipients after SAR-CoV-2 inactivated vaccination.
期 刊:Scientific Reports(影响因子:4.996)
发表时间:4 May 2023
作 者:Zhang L, Yang J, Deng M, et al.
作者单位:广州医科大学
使用产品:TMB底物
https://pubmed.ncbi.nlm.nih.gov/37142713/
23.文章题目:Leocarpinolide B Attenuates Collagen Type II-Induced Arthritis by Inhibiting DNA Binding Activity of NF-κB.
期 刊:Molecules(影响因子:4.927)
发表时间:22 May 2023
作 者:Linghu K G, Zhao G D, Zhang D Y, et al.
作者单位:澳门大学
使用产品:Human CRP ELISA kit
https://www.mdpi.com/1420-3049/28/10/4241
24.文章题目:Integrated network pharmacology and fecal metabolomics analysis of the combinational mechanisms of Shexiang Baoxin Pill against atherosclerosis.
期 刊:Molecular Omics(影响因子:4.212)
发表时间:24 May 2023
作 者:Wang Z, Wan Q, Xie B, et al.
作者单位:华东理工大学
使用产品:Mouse TNF-α ELISA kits
https://pubs.rsc.org/en/content/articlehtml/2023/mo/d3mo00067b
25.文章题目:Bovine pulmonary surfactant alleviates inflammation and epithelial cell apoptosis in the early phase of lipopolysaccharide-induced acute lung injury in rats.
期 刊:Biotechnology and Genetic Engineering Reviews(影响因子:4.2)
发表时间:8 May 2023
作 者:Chen X, Dumbuya J S, Du J, et al.
作者单位:南方医科大学
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37154048/
26.文章题目:APP/PS1 Gene-Environmental Cadmium Interaction Aggravates the Progression of Alzheimer’s Disease in Mice via the Blood-Brain Barrier, Amyloid-β, and Inflammation.
期 刊:Journal of Alzheimer's Disease(影响因子:4.16)
发表时间:20 May 2023
作 者:Liu J, Xie Y, Lu Y, et al.
作者单位:中山大学
使用产品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
https://content.iospress.com/articles/journal-of-alzheimers-disease/jad221205
27.文章题目:CTRP5 Attenuates Doxorubicin-Induced Cardiotoxicity Via Inhibiting TLR4/NLRP3 Signaling.
期 刊:Cardiovascular Drugs and Therapy(影响因子:3.947)
发表时间:31 May 2023
作 者:Zhang Z, Peng J, Hu Y, et al.
作者单位:宁波大学第一附属医院
使用产品:Mouse TNF-αand IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37256416/
28.文章题目:Thalidomide promotes NLRP3/caspase-1-mediated pyroptosis of macrophages in Talaromyces marneffei infection.
期 刊:Microbial Pathogenesis(影响因子:3.848)
发表时间:22 May 2023
作 者:Dong R J, Li J, Zhang Y, et al.
作者单位:昆明医科大学
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37224982/
29.文章题目:Activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 by Porphyromonas gingivalis regulates programmed cell death in epithelium.
期 刊:Journal of Dental Sciences(影响因子:3.719)
发表时间:19 May 2023
作 者:Liu J, Liu W, Lv P, et al.
作者单位:北京大学口腔医学院附属医院
使用产品:Human IL-1β and IL-18 ELISA kits
https://www.sciencedirect.com/science/article/pii/S1991790223001320
30.文章题目:A novel extract from Ginkgo biloba inhibits neuroinflammation and maintains white matter integrity in experimental stroke.
期 刊:Neuroscience(影响因子:3.708)
发表时间:22 May 2023
作 者:Dong W, Gong T, Zhao S, et al.
作者单位:首都医科大学
使用产品:Mouse IL-1β and TNFα ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37225050/
31.文章题目:MicroRNA-31 regulates TNF-α and IL-17A co-induced-endothelial cell apoptosis by repressing E2F6.
期 刊:Biochemical and Biophysical Research Communications(影响因子:3.322)
发表时间:3 May 2023
作 者:Fang Z, Tong X, Shi G, et al.
作者单位:昆明理工大学
使用产品:Mouse TNF-α ELISA kit
https://www.sciencedirect.com/science/article/abs/pii/S0006291X23005685
32.文章题目:Chronic Administration of Methamphetamine Aggravates Atherosclerotic Vulnerable Plaques in Apolipoprotein E Knockout Mice Fed with a High-cholesterol Diet.
期 刊:Current Molecular Medicine(影响因子:2.616)
发表时间:23 May 2023
作 者:Cui X, Gao B, Yu Y, et al.
作者单位:武汉第四医院
使用产品:Anti mouse IgG HRP
https://www.ingentaconnect.com/content/ben/cmm/pre-prints/content-36944618
33.文章题目:Probiotics-loaded microcapsules from gas-assisted microfluidics for inflammatory bowel disease treatment.
期 刊:Macromolecular Research(影响因子:2.127)
发表时间:22 May 2023
作 者:Yang X, Li C, Yu H, et al.
作者单位:九江市第一人民医院
使用产品:Mouse TNF-α ELISA kit
https://link.springer.com/article/10.1007/s13233-023-00166-1
34.文章题目:Effect and Mechanism of Schizandrin A in the Treatment of Liver Cancer Using Network Pharmacology, Molecular Docking, and Target Validation.
期 刊:Natural Product Communications(影响因子:1.496)
发表时间:24 May 2023
作 者:Wang X, Zhou L, Zhang T, et al.
作者单位:大连医科大学第一附属医院
使用产品:Rat IL-1β, TNF-α, IL-6, IL-10 and IFN-γ ELISA kits
https://journals.sagepub.com/doi/full/10.1177/1934578X231176916
35.文章题目:Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice.
期 刊:Iranian Journal of Immunology(影响因子:1.206)
发表时间:31 May 2023
作 者:Niu J, Zhou H, Tian R, et al.
作者单位:中国人民解放军空军医学中心
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37246779/
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