特发性肺纤维化(IPF, Idiopathic pulmonary fibrosis)是一种慢性进行性间质性肺病,最终会导致肺功能永久恶化并死亡。白细胞介素-11 (IL-11)是一种促纤维化细胞因子,对成纤维细胞分化为分泌胶原、肌动蛋白α2、平滑肌阳性(ACTA2+)肌成纤维细胞至关重要,是特发性肺纤维化(IPF)发病机制的驱动过程。最近,上海交通大学药学院在期刊《Science Advances》(IF=14.957)上发表题为“Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.”的文章,开发了一种可吸入和可粘液渗透的纳米颗粒(NP)系统,该系统结合了抗IL11的siRNA(siIL11 @ PPGC NPs ),并研究了其治疗IPF的治疗潜力。NP是通过可生物降解的PLGA-PEG二嵌段共聚物和自创的阳离子类脂分子G0-C14的自组装来配制的,以实现siIL11的有效跨粘膜递送。非侵入性雾化吸入通过抑制ERK和SMAD2来阻止成纤维细胞分化和减少ECM沉积。此外,在博莱霉素诱导的肺纤维化的小鼠模型中,siIL11@PPGC NPs显著减少了纤维化的发展并改善了肺功能,而没有诱导全身毒性。这项研究为siRNA治疗剂的局部吸入给药提供了一个通用的纳米颗粒平台,并在许多呼吸系统疾病(包括IPF)的治疗中显示出有希望的临床潜力。
本文中使用了欣博盛Mouse TGF-β1 ELISA kit检测了肺泡灌洗液样本中的表达量。
1.文章题目:Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.
期 刊:Science Advances(影响因子:14.957)
发表时间:22 June 2022
作 者:Bai X, Zhao G, Chen Q, et al.
作者单位:上海交通大学药学院
使用产品:Mouse TGF-β1 ELISA kit
样本类型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/35731866/
2.文章题目:Functionalizing multi-component bioink with platelet-rich plasma for customized in-situ bilayer bioprinting for wound healing.
期 刊:Materials Today Bio(影响因子:10.761)
发表时间:16 June 2022
作 者:Zhao M, Wang J, Zhang J, et al.
作者单位:第四军医大学
使用产品:Human PDGF-BB ELISA kit
https://www.sciencedirect.com/science/article/pii/S2590006422001326
3.文章题目:Polysialylated Nanoinducer for Precisely Enhancing Apoptosis and Anti-tumor Immune Response in B-cell Lymphoma.
期 刊:Acta Biomaterialia(影响因子:10.633)
发表时间:7 June 2022
作 者:Zhang Q, Li S, Guo K, et al.
作者单位:四川电子科技大学
使用产品:Mouse IFN-γ, TNF-α, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35779772/
4.文章题目:ROS-triggered nanoinducer based on dermatan sulfate enhances immunogenic cell death in melanoma.
期 刊:Journal of Controlled Release(影响因子:9.776)
发表时间:1 June 2022
作 者:Zhang Q, Li S, Ren J, et al.
作者单位:四川电子科技大学
使用产品:Mouse IFN-γ, TNF-α, IL-6 and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35461966/
5.文章题目:Antibiotics-free nanoparticles eradicate Helicobacter pylori biofilms and intracellular bacteria.
期 刊:Journal of Controlled Release(影响因子:9.776)
发表时间:16 June 2022
作 者:Zou Y, Chen X, Sun Y, et al.
作者单位:中山大学药学院
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35662575/
6.文章题目:Silver nanoclusters show advantages in macrophage tracing in vivo and modulation of anti-tumor immuno-microenvironment.
期 刊:Journal of Controlled Release(影响因子:9.776)
发表时间:5 June 2022
作 者:Yan X, Qi Y, Ren L, et al.
作者单位:中国科学院生态环境科学研究中心
使用产品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35691499/
7.文章题目:Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure.
期 刊:Particle and fibre toxicology(影响因子:9.112)
发表时间:23 June 2022
作 者:Zhang R, Chen S, Chen L, et al.
作者单位:中山大学公共卫生学院
使用产品:Mouse IL-17A and TGF-βELISA kits
样本类型:肺组织
https://pubmed.ncbi.nlm.nih.gov/35739565/
8.文章题目:Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein.
期 刊:Critical Care(影响因子:9.097)
发表时间:9 June 2022
作 者:Zhang L, Zhang Y, Qin X, et al.
作者单位:重庆医科大学
使用产品:Mouse IL-6, TNF-α, IL-1β ELISA kits
样本类型:支气管肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/35681221/
9.文章题目:A Cell Membrane Repair-Based Nanoformulation with Multiple Actuators for Scarless Wound Healing.
期 刊: Journal of Materials Chemistry B(影响因子:7.571)
发表时间:29 June 2022
作 者:Zhang X, Wu Z, Sun J, et al.
作者单位:天津医科大学
使用产品:Mouse IL-1βand IL-6 ELISA kits
https://pubs.rsc.org/en/content/articlelanding/2022/tb/d2tb00992g/unauth
10.文章题目:Dynamic Monitoring of Immunoinflammatory Response Identifies Immunoswitching Characteristics of Severe Acute Pancreatitis in Rats.
期 刊:Frontiers in immunology(影响因子:7.561)
发表时间:12 June 2022
作 者:Zhuang Q, Huang L, Zeng Y, et al.
作者单位:西南医科大学
使用产品:Rat IL-8 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35663952/
11.文章题目:Dengue virus is involved in insulin resistance via the downregulation of IRS-1 by inducing TNF-α secretion.
期 刊:Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease(影响因子:6.633)
发表时间:22 June 2022
作 者:Liu X, Liang Z, Duan H, et al.
作者单位:南方医科大学公共卫生学院
使用产品:Human TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35752384/
12.文章题目:Reduced Virulence and Enhanced Host Adaption during Antibiotics Therapy: a Story of a Within-Host Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Evolution in a Patient with a Serious Scrotal Abscess.
期 刊: Msystems(影响因子:6.496)
发表时间:1 June 2022
作 者:Ye M, Liao C, Shang M, et al.
作者单位:同济大学医学院
使用产品:Mouse TNF-α, IL-6, and IL-1βELISA kits
https://pubmed.ncbi.nlm.nih.gov/35196132/
13.文章题目:Integrating inflammation-responsive prodrug with electrospun nanofibers for anti-inflammation application.
期 刊:Pharmaceutics(影响因子:6.321)
发表时间:13 June 2022
作 者:Ye J, Gong M, Song J, et al.
作者单位:北京化工大学
使用产品:Mouse IL-6 ELISA kit
https://www.mdpi.com/1999-4923/14/6/1273
14.文章题目:Cinnamaldehyde protect against ligature-induced periodontitis through inhibitions of microbial accumulation and inflammatory responses of host immune cells
期 刊:Food & Function(影响因子:6.317)
发表时间:22 June 2022
作 者:Ou Y, Yan M, Gao G, et al.
作者单位:福建三明大学
使用产品:Mouse IL-6, IL-8, IL-1β and TNF-α ELISA kits
样本类型:牙周组织
https://pubs.rsc.org/en/content/articlehtml/2022/fo/d2fo00963c
15.文章题目: Exosomes Derived From Dendritic Cells Infected With Toxoplasma gondii Show Antitumoral Activity in a Mouse Model of Colorectal Cancer.
期 刊:Frontiers in oncology(影响因子:6.244)
发表时间:7 June 2022
作 者:Lu J, Wei N, Zhu S, et al.
作者单位:华南农业大学
使用产品:Mouse IL-6 and GM-CSF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35600363/
16.文章题目:Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer.
期 刊:Acta Pharmacologica Sinica(影响因子:6.15)
发表时间:15 June 2022
作 者:Zhao Z, Wang J, Fang L, et al.
作者单位:复旦大学药学院
使用产品:Human IgG ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35705687/
17.文章题目:Hepatoprotective effect of curcumin against bisphenol A-induced hepatic steatosis via modulating gut microbiota dysbiosis and related gut-liver axis activation in CD-1 mice.
期 刊:The Journal of Nutritional Biochemistry(影响因子:6.117)
发表时间:30 June 2022
作 者:Hong T, Jiang X, Zou J, et al.
作者单位:中山大学公共卫生学院
使用产品:Mouse TNFα, IL-1β, IL-6 and IL-18 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S095528632200167X
18.文章题目: Qiliqiangxin Modulates the Gut Microbiota and NLRP3 Inflammasome to Protect Against Ventricular Remodeling in Heart Failure.
期 刊:Frontiers in pharmacology(影响因子:5.988)
发表时间:2 June 2022
作 者:Lu Y, Xiang M, Xin L, et al.
作者单位:中国中医科学院
使用产品:Rat TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35721118/
19.文章题目:A Type Ib Crustin from Deep-Sea Shrimp Possesses Antimicrobial and Immunomodulatory Activity.
期 刊:International Journal of Molecular Sciences(影响因子:5.923)
发表时间:7 June 2022
作 者:Wang Y J, Sun L.
作者单位:中国科学院海洋大科学中心海洋研究所
使用产品:Mouse IL-1β ELISA kit
https://www.mdpi.com/1422-0067/23/12/6444
20.文章题目:Pentapeptide AYP from Isochrysis Zhanjiangensis Exhibits Antiangiogenic Activity in HT1080 Cells and HUVECs by Suppressing Migration and Invasion In Vitro.
期 刊:Journal of Agricultural and Food Chemistry(影响因子:5.895)
发表时间:29 June 2022
作 者:Tang Y, Yang S, Lin L, et al.
作者单位:广东海洋大学
使用产品:Human VEGF, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35770804/
21.文章题目:High fluoride ingestion impairs bone fracture healing and attenuating M2 macrophages differentiation.
期 刊:Frontiers in Bioengineering and Biotechnology(影响因子:5.89)
发表时间:20 June 2022
作 者:Du C C, Xiao P, Gao S, et al.
作者单位:重庆医科大学附属第一医院
使用产品:Mouse CCL2, IL-8, VEGF and TGF-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35669059/
22.文章题目:Protective effects of (R)-enantiomers but not (S)-enantiomers of β2-adrenergic receptor agonists against acute colitis: The role of β2AR.
期 刊:International Immunopharmacology(影响因子:5.714)
发表时间:26 June 2022
作 者:Deng L, Wang S, Zhang R, et al.
作者单位:广东工业大学
使用产品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35767902/
23.文章题目:Characterization of the pathogenicity of a Bacillus cereus isolate from the Mariana Trench.
期 刊:Virulence(影响因子:5.428)
发表时间:22 June 2022
作 者:Wang Y, Zhang J, Yuan Z, et al.
作者单位:中国科学院海洋大科学中心海洋研究所
使用产品:Mouse IL-1β and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35733351/
24.文章题目:The Intracellular Interaction of Porcine β-Defensin 2 with VASH1 Alleviates Inflammation via Akt Signaling Pathway.
期 刊:The Journal of Immunology(影响因子:5.422)
发表时间:16 June 2022
作 者:Huang C, Sun Y, Qiu X, et al.
作者单位:华中农业大学
使用产品:Mouse VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35688466/
25.文章题目:Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway.
期 刊:Journal of Cellular and Molecular Medicine(影响因子:5.31)
发表时间:1 June 2022
作 者:Yuan L, Yang J, Li Y, et al.
作者单位:四川大学华西医院
使用产品:Mouse TNF-α, IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35650472/
26.文章题目:The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity.
期 刊:Scientific reports(影响因子:4.996)
发表时间:21 June 2022
作 者:Zhang S, Gu C, Huang L, et al.
作者单位:武汉科技大学
使用产品:Human IL-6 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35729339/
27.文章题目:Mechanism of two alkaloids isolated from coral endophytic fungus for suppressing angiogenesis in atherosclerotic plaque in HUVEC.
期 刊:International Immunopharmacology(影响因子:4.932)
发表时间:5 June 2022
作 者:Liu Y, Li Y, Chen M, et al.
作者单位:广东海洋大学
使用产品:Human IL-1β, IL-6, TNF-α and PDGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35704971/
28.文章题目:PKM2 regulates cigarette smoke-induced airway inflammation and epithelial-to-mesenchymal transition via modulating PINK1/Parkin-mediated mitophagy.
期 刊:Toxicology(影响因子:4.571)
发表时间:7 June 2022
作 者:Li D, Shen C, Liu L, et al.
作者单位:四川大学华西医院
使用产品:Mouse TNF-α, IL-6 and IL-8 ELISA kits
样本类型:肺泡灌洗液
https://www.sciencedirect.com/science/article/pii/S0300483X22001639
29.文章题目:Hemp Seed Fermented by Aspergillus oryzae Attenuates Lipopolysaccharide-Stimulated Inflammatory Responses in N9 Microglial Cells.
期 刊: Foods(影响因子:4.35)
发表时间:6 June 2022
作 者:Wang Z, Wu L, Fu D, et al.
作者单位:大连工业大学
使用产品:Mouse IL-6 ELISA kit
https://www.mdpi.com/2304-8158/11/12/1689
30.文章题目:Gasdermin D-mediated microglial pyroptosis exacerbates neurotoxicity of aflatoxins B1 and M1 in mouse primary microglia and neuronal cultures.
期 刊:NeuroToxicology(影响因子:4.294)
发表时间:12 June 2022
作 者:Zhang J, Su D, Liu Q, et al.
作者单位:贵州中医药大学
使用产品:Mouse IL-1β, TNF-α, IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35716928/
31.文章题目:MCPIP1 promotes cell proliferation, migration and angiogenesis of glioma via VEGFA-mediated ERK pathway.
期 刊:Experimental Cell Research(影响因子:4.145)
发表时间:19 June 2022
作 者:Wang R, Sun S, Wang Z, et al.
作者单位:安徽医科大学
使用产品:Human VEGF ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35752346/
32.文章题目:PINK1‐mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages.
期 刊:Oral Diseases(影响因子:4.068)
发表时间:22 June 2022
作 者:Jiang K, Li J, Jiang L, et al.
作者单位:南京大学医学院
使用产品:Mouse IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35730318/
33.文章题目:A20 inhibits periodontal bone resorption and NLRP3-mediated M1 macrophage polarization.
期 刊:Experimental Cell Research(影响因子:3.905)
发表时间:12 June 2022
作 者:Hou L, Ye Y, Gou H, et al.
作者单位:南京医科大学
使用产品:Human IL-1β, TNF-α ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35714941/
34.文章题目:The stability of dry‐cured ham derived peptides and its anti‐inflammatory effect in RAW264. 7 macrophage cells.
期 刊:International Journal of Food Science & Technology(影响因子:3.713)
发表时间:7 June 2022
作 者:Xing L, Fu L, Toldrá F, et al.
作者单位:南京农业大学
使用产品:Mouse TNF-α ELISA kit
https://ifst.onlinelibrary.wiley.com/doi/abs/10.1111/ijfs.15800
35.文章题目:Association Between Circulating Cell-Free DNA Level at Admission and the Risk of Heart Failure Incidence in Acute Myocardial Infarction Patients.
期 刊:DNA and Cell Biology(影响因子:3.55)
发表时间:28 June 2022
作 者:Zhang Q, He X, Ling J, et al.
作者单位:湖南省人民医院
使用产品:Human ST2 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35763313/
36.文章题目:Berberine protects against chronic cerebral hypoperfusion-induced cognitive impairment and hippocampal damage via regulation of the ERK/Nrf2 pathway.
期 刊:Journal of Chemical Neuroanatomy(影响因子:3.052)
发表时间:8 June 2022
作 者:Wang N, Tian Y, Zhao F, et al.
作者单位:首都医科大学
使用产品:Rat VEGF, MMP-9 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/35697268/
37.文章题目:MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.
期 刊: Molecular Biology Reports(影响因子:2.742)
发表时间:1 June 2022
作 者:Li T, Chen Q, Dai J, et al.
作者单位:重庆医科大学
使用产品:Human IL-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35644004/
38.文章题目:Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis.
期 刊:Computational and Mathematical Methods in Medicine(影响因子:2.238)
发表时间:5 June 2022
作 者:Chen G, Liu X, Luo J, et al.
作者单位:北京中医药大学
使用产品:Rat IL-18 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/35720033/
39.文章题目:Generation of a human embryonic stem cell line (SMUDHe010-A-82) carrying a homozygous c. 1538G> A (p. G513D) mutation in the OSMR gene by CRISPR/Cas9-mediated homologous recombination.
期 刊:Stem Cell Research(影响因子:2.02)
发表时间:9 June 2022
作 者:Zheng W, Zhong Y, Yuan L, et al.
作者单位:南方医科大学
使用产品:BSA
https://pubmed.ncbi.nlm.nih.gov/35714449/
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