产品描述:
Mogrol is an aglycone form of various mogrosides that has been found in S. grosvenorii and has diverse biological activities.{65829,65830,65831} It inhibits the proliferation and migration of A549, H1299, H1975, and SK-MES-1 lung cancer cells when used at concentrations ranging from 10 to 50 µM.{65829} Mogrol (50 µM) induces AMPK activation and autophagy, as well as apoptosis and cell cycle arrest at the G1 phase in A549 cells. In vivo, mogrol (10 mg/kg) reduces tumor weight and volume in an A549 mouse xenograft model. Mogrol (5 mg/kg) reduces colonic inflammatory cell infiltration and colonic shortening in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; Item No. 23250).{65830} It also improves LPS-induced memory impairments and decreases hippocampal and frontal cortex levels of TNF-α, IL-1β, and IL-6 in LPS-challenged mice.{65831}