产品描述:
BTSA1 is an activator of Bax.{72077} It binds to the Bax N-terminal activation site, also known as the trigger site (IC50 = 250 nM), and induces Bax translocation membrane permeabilization in liposomes when used at concentrations ranging from 100 to 400 nM. BTSA1 (0.1-1 µM) induces apoptosis in various human and mouse acute myeloid leukemia (AML) cell lines. In vivo, BTSA (10 mg/kg) reduces bone marrow infiltration and promotes apoptosis in bone marrow infiltrates in a MOLM-13 AML mouse xenograft model.