产品描述:
AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC50 = 11.7 μM).{23464} It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.{23464} AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, a known target of AMPK.{23464} AMPK activator also decreases blood glucose concentrations in female Zucker diabetic rats, demonstrating its utility in whole animals.{23464} At 50 μM, it inhibits the growth of multiple myeloma cells.{23463} AMPK activator induces phosphorylation of raptor in PC3 prostate cancer cells, down-regulating mTORC1 signaling and reducing survivin expression.{23465}