产品描述:
Ezutromid is a modulator of utrophin production.{32729} It upregulates utrophin production in mouse myoblasts (EC50 = 0.91 µM in a reporter assay).{68213} It inhibits the activity of the cytochrome P450 (CYP) isoform CYP1A2 in pooled human liver microsomes (IC50 = 5.4 µM).{68214} Chronic administration of ezutromid (50 mg/kg) increases utrophin protein levels in the heart, increases grip strength, and decreases fatigue, indicated by distance traveled during forced exercise, in the mdx mouse model of muscular dystrophy.{32729}