产品描述:
Siramesine is an agonist of the sigma-2 (σ2) receptor (IC50 = 0.19 nM).{34005} It is selective for σ2 over σ1 (IC50 = 17 nM) and related receptors and transporters.{34005} Siramesine is anxiolytic without inducing sedation or impairing motor coordination in animal studies.{34005} It is known to induce the death of cancer cells in vitro by destabilizing lysosomes, although it has also been shown to destabilize mitochondria and, with lapatinib (Item No. 11493), induce ferroptosis.{34002,34003,34004}