产品描述:
Phorbol 12,13-dibutyrate is a phorbol ester and an activator of PKC, including group A (α and γ) and group B (δ, ε, η) PKC isoforms.{45312} It promotes tumor formation to a lesser degree than phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{45313} Phorbol 12,13-dibutyrate induces papilloma formation in mice with a total dose of 9.7 µmol required to produce papillomas in 50% of survivors after eight weeks.{45314} It also induces inflammation in 50% of mice when administered topically to the ear at a dose of 0.067 µmol/ear.