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产品名称:
DcR1 peptide
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别名:
Tnf Receptor Superfamily Member 10C , Cd263 , Dcr1 , Dcr1-Tnfr , Lit , Trail-R3 , Trailr3 , Trid , Tnfrsf10C
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产品描述:
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反应种属:
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宿主来源:
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实验应用:
Neutralizing/Inhibition
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靶标/特异性:
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同种型:
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免疫原:
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克隆性:
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纯化方式:
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偶联:
Unconjugated
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产品浓度:
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
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表达系统:
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阳性对照:
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保存温度:
Store the peptide at -20ºC, stable for one year.
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运输温度:
dry ice
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细胞定位:
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预期分子量:
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产品形式:
Liquid
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存储溶液:
PBS pH7.2, 10mM NaH₂PO₄, 10mM Na₂HPO₄, 130mM NaCl, 0.1% BSA
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有效期:
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产地:
美国
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外观:
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功能与背景:
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
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样本类型:
PBS pH7.2, 10mM NaH₂PO₄, 10mM Na₂HPO₄, 130mM NaCl, 0.1% BSA
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