产品描述:
st-Ht31 is a cell-permeable stearated peptide derived from the amphipathic helix domain from A-kinase anchoring proteins (AKAPs), which binds protein kinase A (PKA).{68531,68532} It decreases PKA membrane anchoring but not activity in a reporter assay using BHK-21 fibroblasts when used at a concentration of 50 µM.{68532} st-Ht31 (1 and 3 µM) reduces capacitance and hyperactivation, as well as prevents in vitro fertilization, in mouse sperm.{68531} It increases cholesterol export from BHK-21 cells and RAW 264.7 macrophages expressing ATP-binding cassette transporter 1 (ABCA1) when used at a concentration of 50 µM.{68532}