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Pap12-6 (trifluoroacetate salt)
品牌： Cayman
产品货号： 37454-1 mg
规格： 1 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Pap12-6 (trifluoroacetate salt)
  • 别名:
  • 产品描述:
    Pap12-6 is an antibacterial peptide derived from the twelve N-terminal amino acids of the peptide papiliocin, which has been found in P. xuthus larvae.{51476} It is active against a panel of eight Gram-negative bacteria, including E. coli, P. aeruginosa, and S. syphimurium (MIC50s = 4-8 µM), and the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus 3126 (MRSA-3126), B. subtilis, and S. epidermidis (MIC50s = 4-8 µM) without affecting the viability of human erythrocytes, mouse RAW 264.7 macrophages, human HaCaT keratinocytes, or human HEK293 kidney cells at 25 µM. Pap12-6 induces membrane depolarization in E. coli when used at concentrations of 4 and 8 µM. Preincubation with Pap12-6 (10 µM) reduces nitrite (NO2-), Tnf-α, and Il-6 secretion levels in LPS-stimulated RAW 264.7 macrophages. In vivo, Pap12-6 (10 mg/kg) increases survival in mice infected with E. coli, as well as reduces the number of colony forming units (CFUs) in the lungs, liver, and kidneys in E. coli-infected mice when administered at a dose of 1 mg/kg. Pap12-6 (1 mg/kg) reduces serum aspartate aminotransferase (AST) and alanine transaminase (ALT) levels and blood urea nitrogen levels in a mouse model of E. coli-induced sepsis.
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    1645.1
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥95%
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  • 分子式:
    C83H133N23O12 • XCF3COOH
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