Monoacylglycerol Lipase Inhibitor Screening Assay Kit - 深圳欣博盛生物科技有限公司

您现在的位置：首页 > 产品目录 > 产品分类 > 其他试剂 > 特色试剂盒 > 比色法检测试剂盒

Monoacylglycerol Lipase Inhibitor Screening Assay Kit

品牌： Cayman

产品货号： 705192

规格： 96 wells

报价：

折后价：

数量： - +

问题咨询

官网链接

说明书

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Monoacylglycerol Lipase Inhibitor Screening Assay Kit
别名:

MAGL|MGL
产品描述:

The endocannabinoid system is a ubiquitous lipid signaling system that is involved in various regulatory functions throughout the body. The main endocannabinoids are arachidonoyl ethanolamide (AEA) and 2-arachidonoyl glycerol (2-AG). They bind to G protein-coupled receptors, of which the cannabinoid (CB1) receptor is densely distributed in areas of the brain related to motor control, cognition, emotional responses, and homeostasis.{7183,4614,6819,14061} Acting via the CB2 receptor in the peripheral tissues, the endocannabinoid system is one of the crucial modulators of the autonomic nervous system, the immune system, and microcirculation. Endocannabinoids are released upon demand from lipid precursors in a receptor-dependent manner. They are transported into cells by an apparently specific uptake system and degraded primarily by two enzymes, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) resulting in the termination of their biological actions.{11364} FAAH, a serine hydrolase, can degrade many fatty acid amides, including AEA. Although FAAH can hydrolyze 2-AG, the main enzyme responsible for the inactivation of this monoglyceride is another serine hydrolase, MAGL. Finding inhibitors to these endocannabinoid hydrolases could offer another approach in the treatment of pain, obesity, and various neurological diseases, where higher endocannabinoid activity would be beneficial. An advantage of such enzyme inhibition over direct cannabinoid agonists could result in higher selectivity, as it would increase activity of the endocannabinoid system only at sites where on-going production of endocannabinoids is taking place.{14062} Cayman’s Monoacylglycerol Lipase Inhibitor Screening Assay provides a convenient method for screening human MAGL inhibitors. MAGL hydrolyzes 4-nitrophenylacetate resulting in a yellow product, 4-nitrophenol, with an absorbance of 405-412 nm.{16685}
反应种属:
宿主来源:
实验应用:
靶标/特异性:
同种型:
推荐稀释度:
免疫原:
免疫原种属:
克隆性:
克隆号:
纯化方式:
偶联:
产品浓度:
表达系统:
阳性对照:
保存温度:

-80
运输温度:

-80
细胞定位:
预期分子量:
产品形式:
存储溶液:
有效期:

365
产地:

美国
外观:
生产商:
功能与背景:
URL:
灵敏度:
检测范围:
检测方法:
样本类型:
产品特点:
纯度:
生物活性:
内毒素水平:
来源:
表达方式:
Accession #:
CAS号:
分子式:
溶解度:
PubChem CID: