产品描述:
Annaosanchun is a synthetic sterol and neuroprotectant agent.{69662} It increases the viability of, and the levels of ATP and the mitochondrial membrane potential in, hypoxia-exposed and reoxygenated primary rat cortical neurons when used at concentrations of 0.1, 0.3, and 1 µM. Annaosanchun (10 µM) prevents glutamate-induced increases in intracellular acidification, lactate levels, and glycolysis rate, as well as inhibits glutamate-induced apoptosis, in primary rat cerebral granule neurons.{69663} It reduces neurological and neuromuscular deficits and infarct volume in a rat model of ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at doses of 0.5, 2, or 10 mg/kg.