产品描述:
Mebendazole-d8 is intended for use as an internal standard for the quantification of mebendazole (Item No. 18872) by GC- or LC-MS. Mebendazole is an inhibitor of microtubule polymerization and an anthelmintic.{30620} It reduces microtubule polymerization in a cell-free assay when used at a concentration of 10 µM. Mebendazole reduces container attachment, a measure of viability, by G. duodenalis with a half-maximal inhibition of binding (IB50) value of 190 nM.{30623} It reduces the proliferation of SK-MEL-19 and M14 melanoma cell lines (IC50s = 300 and 320 µM, respectively) and induces apoptosis and poly(ADP-ribose) polymerase (PARP) cleavage in SK-MEL-19 and M14 cells, but not melanocytes, when used at a concentration of 1 µM.{30621} It decreases oxidative stress-induced cell death in primary mouse cortical neurons in a concentration-dependent manner.{30620} In vivo, mebendazole (800 µg/animal every other day) decreases tumor volume, weight, hemoglobin levels, and vascularization in an H460 lung cancer mouse xenograft model.{30624} Mebendazole (8.8 mg/kg) eradicates S. vulgaris, S. edentates, and S. equinus worm burden in infected ponies.{65906} Formulations containing mebendazole have been used in the treatment of helminth gastrointestinal infections.