产品描述:
Valerenic acid is a sesquiterpenoid that has been found in V. officinalis and has diverse biological activities.{61169,63127,72189,72190,72191} It selectively transactivates retinoid X receptor β (RXRβ) over RXRα and RXRγ in reporter assays using HEK293T cells (EC50s = 5.2, 27, and 43 µM, respectively), as well as the retinoic acid receptors (RARs), peroxisome proliferator-activated receptors (PPARs), liver X receptors (LXRs), farnesoid X receptor (FXR), constitutive androstane receptor (CAR), vitamin D receptor (VDR), and pregnane X receptor (PXR) at 30 µM.{63127} Valerenic acid also enhances GABA-induced activation of α1β2γ2-subunit containing GABA receptors in CHO cells (EC50 = 12.6 µM).{72189} It is cytotoxic to GLC-4 lung and COLO 320 colon cancer cells (IC50s = 127 and 124 µM, respectively).{61169} Valerenic acid (100 mg/kg, i.p.) decreases motor performance in the rotarod test and increases pentobarbital-induced sleeping time in mice.{72190} It increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, when administered at a dose of 12 mg/kg.{72191}