产品描述:
SB-4 is an activator of bone morphogenetic protein 4 (BMP4) signaling.{51511} It induces BMP4 signaling in a reporter assay using HEK293 cells expressing a recombinant human BMP4 response element (EC50 = 74 nM). SB-4 (10 µM) increases phosphorylation of SMAD1, -5, and -9 in HEK293 cells. It also induces Blimp1 and Tfap2c expression, markers of germline differentiation, in mouse embryonic stem cells.{51510}