产品描述:
CCMI is a positive allosteric modulator (PAM) of α7 nicotinic acetylcholine receptors (nAChRs).{51518} It enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively). In vivo, CCMI (0.3 and 1 mg/kg, i.v.) improves sensory gating deficits in a paired auditory stimulus paradigm in mice. It decreases the latency to find the platform in the Morris water maze test in a rat model of traumatic brain injury (TBI) induced by parasagittal fluid-percussion.{51519}