产品描述:
(+)-Praeruptorin B is a pyranocoumarin that has been found in P. praeruptorum and has diverse biological activities.{36658,68550,68551,68552} It inhibits RANKL-induced osteoclastogenesis of primary mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 10 µM and LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages at 100 µM.{68550,36658} (+)-Praeruptorin B inhibits platelet aggregation induced by platelet-activating factor (PAF) in isolated rabbit platelet-rich plasma (IC50 = 50 µM) and contractions of isolated guinea pig ileum induced by histamine (Item No. 22328) or leukotriene D4 (pD2s = 4.84 and 4.34, respectively).{68551} It decreases ovariectomy-induced bone loss in a mouse model of osteoporosis when administered at a dose of 10 mg/kg. (+)-Praeruptorin B (10 µmol/animal) reduces the number of tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBA; Item No. 30383) and promoted by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in a mouse two-stage model of skin carcinogenesis.{68552}