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Phosphoramidon . disodium salt
品牌： Adipogen
产品货号： AG-CP3-7008-M025
规格： 25 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Phosphoramidon . disodium salt
  • 别名:
    N-[N-[[(6-Deoxy-alpha-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt; NSC 694280
  • 产品描述:
    Phosphoramidon is a potent, reversible and competitive inhibitor of multiple soluble and membrane-bound zinc metalloproteases, particularly gluzincins, such as neutral endopeptidase NEP (Neprilysin; CD10; EC 3.4.24.11) (Ki = 2nM), NEP2 (Neprilysin-2) (Ki ~ 2nM), or endothelin-converting enzyme (ECE) (IC50 = 0.68µM). It inhibits the thermostable neutral metalloproteinase enzyme thermolysin and the integral membrane protein zinc metalloprotease ZMPSTE24. It has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin and angiotensin-converting enzyme. Shows anti-inflammatory, anti-neurodegenerative and cardioprotective properties. Blocks through NEP degradation of amyloid beta peptides and increases Abeta levels in rodents, indicating that abnormal amyloid processing in Alzheimer's disease may be carried out by a metalloendopeptidase. Plays also a role in the regulation of neuropeptide signaling and in the metabolism of bioactive peptides, such as bradykinin, neurotensin and enkephalin, via plasma membranes. Blocks the formation of endothelin-1, a proinflammatory mediator implicated in the pathogenesis of a variety of lung diseases.
  • 反应种属:
  • 宿主来源:
    Synthetic. Originally isolated from Streptomyces tanashiensis.
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  • 阳性对照:
  • 保存温度:
    -20°C
  • 运输温度:
    Ambient
  • 细胞定位:
  • 预期分子量:
    541.5 . 46.0
  • 产品形式:
    solid
  • 存储溶液:
  • 有效期:
    Stable for at least 2 years after receipt when stored at -20°C.
  • 产地:
    瑞士
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  • 纯度:
    >98% (HPLC)
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  • CAS号:
    164204-38-0
  • 分子式:
    C23H32N3O10P . 2Na
  • 溶解度:
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