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Loxistatin acid [E-64c]
品牌: Adipogen
产品货号: AG-CP3-7007-M005
规格: 5 mg

报价:
折后价:

数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    Loxistatin acid [E-64c]
  • 别名:
    Ep 475; 2S,3S-trans-(Carboxyoxirane-2-carbonyl)-L-leucine-(3-methylbutyl) amide; NSC 694279
  • 产品描述:
    E-64c is a potent cell-impermeable epoxysuccinyl peptide inhibitor of calpain and other cysteine proteases, such as papain, cathepsin B, H and L. Does not inhibit the serine proteases trypsin, chymotrypsin or elastase. E-64c is an active metabolite of the protease inhibitor E-64d (Prod. No. AG-CR1-3737), and a synthetic analog of E-64 (Prod. No. AG-CP3-7006). Studies indicate that E-64c is a more potent inhibitor of cathepsins B and L compared to E-64. E-64c has in vitro antiviral, antiparasitic and immunomodulatory properties. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease, reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with SARS-CoV spike glycoprotein in a concentration-dependent manner, inhibits human rotavirus replication, and exhibits entry-blocking effects against MERS-CoV. It also inhibits the trypanosomal cysteine protease cruzain. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.
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    Synthetic.
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  • 保存温度:
    -20°C
  • 运输温度:
    Ambient
  • 细胞定位:
  • 预期分子量:
    314.4
  • 产品形式:
    solid
  • 存储溶液:
  • 有效期:
    Stable for at least 2 years after receipt when stored at -20°C.
  • 产地:
    瑞士
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  • 纯度:
    >98% (HPLC)
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  • CAS号:
    76684-89-4
  • 分子式:
    C15H26N2O5
  • 溶解度:
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