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Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)
品牌： Adipogen
产品货号： IAX-200-021-3005
规格： 3 x 5 mg

报价：
折后价：

数量： - +
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  • 产品名称:
    Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)
  • 别名:
    Polyinosinic-polycytidylic acid, potassium salt (poly (I:C))
  • 产品描述:
    Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
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  • 阳性对照:
  • 保存温度:
    +4°C
  • 运输温度:
    AMBIENT
  • 细胞定位:
  • 预期分子量:
    High molecular weight (>1.5kb).
  • 产品形式:
    solid
  • 存储溶液:
    Lyophilized. Sterile.
  • 有效期:
    Stable for at least 2 years after receipt when stored at +4°C.
  • 产地:
    瑞士
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  • 样本类型:
    Lyophilized. Sterile.
  • 产品特点:
  • 纯度:
    >99%
  • 生物活性:
    Activates TLR3, MDA5/Helicard and RIG-I. Optimal working concentration depends upon target receptor accessibility, number, density, as well as cell type, and therefore needs to be determined for each application. Recommended concentration range: in vitro: 0.5-10µg/ml; in vivo: 5mg/kg.
  • 内毒素水平:
    <0.002EU/µg
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  • CAS号:
    31852-29-6
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