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产品名称:
FTY720 Hydrochloride
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别名:
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol,hydrochloride; Fingolimod
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产品描述:
S1P receptor ligand
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同种型:
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阳性对照:
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保存温度:
-20ºC
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运输温度:
Shipped Ambient
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细胞定位:
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预期分子量:
343.9
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产品形式:
White solid
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存储溶液:
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有效期:
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产地:
加拿大
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功能与背景:
FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4).
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纯度:
>98% (TLC); NMR (Conforms)
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来源:
Synthetic
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Accession #:
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CAS号:
162359-56-0
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分子式:
C19H34ClNO2
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溶解度:
Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)
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PubChem CID:
107969