产品描述:
BAY-2416964 is an antagonist of the aryl hydrocarbon receptor (AhR; IC50 = 22 nM in U87 cells).{72306} It decreases the mRNA expression of the AhR target genes CYP1A1 and AHRR induced by the AhR agonist kynurenic acid (Item No. 16792) in LPS-stimulated isolated human monocytes when used at a concentration of 100 nM. BAY-2416964 (30-1,000 nM) increases CD3-, CD28-, and IL-2-induced IFN-γ production in isolated human naïve CD4+ T cells. In vivo, BAY-2416964 (30 mg/kg, p.o.) reduces tumor volume, increases CD8+ T cell and natural killer (NK) cell tumor infiltration, and decreases GR1+ myeloid cell and CD206+ M2 macrophage tumor infiltration in a B16/F10-OVA murine melanoma model.