产品描述:
Isopteropodine is an oxindole alkaloid that has been found in U. tomentosa and has diverse biological activities.{51656,51657,51658,51659} It induces activation of the pregnane X receptor (PXR) in a reporter assay using DPX2 cells expressing the human receptor (EC50 = 0.7656 µM).{51656} Isopteropodine is a positive modulator of M1 muscarinic acetylcholine receptors (mAChRs) and the serotonin (5-HT) receptor subtype 5-HT2 (EC50s = 9.92 and 14.5 µM for the rat receptors, respectively).{51657} It is active against S. aureus and B. subtilis (MICs = 408 and 679 µM, respectively).{51658} Isopteropodine (100 µM) inhibits the proliferation of CCRF CEM C7H2 lymphoblastic leukemia cells.{51659}