产品描述:
Ombuin is a flavonoid that has been found in B. balsamifera and has diverse biological activities.{58738,72263,72264,72265} It is an antagonist of M1 muscarinic acetylcholine receptors (mAChRs; Ki = 42 µM in CHO-K1 cells expressing the human receptor).{72263} Ombuin is cytotoxic to HepG2 hepatocellular carcinoma cells (IC50 = 1.5 µg/ml).{72264} In vivo, ombuin (40 mg/kg per day) reduces blood urea and glucose levels, urinary volume and protein levels, serum creatinine levels, renal fibrosis levels, and body weight in a rat model of diabetic nephropathy induced by streptozotocin (STZ; Item No. 13104).{72265}