产品描述:
Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson's disease symptoms such as involuntary tremor and dystonia.