产品描述:
ST1936 is an agonist of the serotonin (5-HT) receptor subtype 5-HT6.{66562,66563} It selectively binds to 5-HT6 (Ki = 31 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A, and the serotonin transporter (SERT; Kis = >1,000 nM for all) but also binds to the 5-HT7 receptor (Ki = 168 nM).{66562} ST1936 induces cAMP accumulation in BHK fibroblasts (EC50 = 16 nM).{66563} It decreases the basal firing rate of dopaminergic neurons in the ventral tegmental area but not substantia nigra pars compacta in rats in a dose-dependent manner.{66564} ST1936 (10 and 30 mg/kg) prevents stress-induced decreases in vanilla sugar-sustained appetitive behavior, indicating anti-anhedonic-like activity, in rats.{66565} It induces self-administration in rats when administered at a dose of 1 mg/kg.{66566}