产品描述:
JHU37160 is an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (mAChRs).{67566} It binds to hM3Dq and hM4Di receptors (Kis = 1.9 and 3.6 nM, respectively) and induces Gαo1 activation in HEK293 cells expressing hM3Dq or hM4Di (EC50s = 18.5 and 0.2 nM, respectively). In vivo, JHU37160 (0.01-1 mg/kg) inhibits locomotor activity in D1-hM3Dq and D1-hM4Di transgenic mice.