产品描述:
4-Nonylphenol-2,3,5,6-d4 is intended for use as an internal standard for the quantification of 4-nonylphenol by GC- or LC-MS. 4-Nonylphenol is a degradation product of the nonionic surfactant nonylphenol ethoxylate and an endocrine disruptor.{66547} It induces estrogen receptor α (ERα) reporter gene expression in MCF-7 cells expressing the human receptor when used at a concentration of 100 nM.{66548} 4-Nonylphenol (20 µM) decreases triglyceride accumulation and reduces expression of the adipogenesis marker genes Pparγ1, Pparγ2, Cebpa, Cebpβ, and Fabp4 in differentiated 3T3-L1 adipocytes but promotes triglyceride accumulation and adipogenesis in C3H/10T1/2 mesenchymal stem cells (MSCs).{66549} It has been found as a contaminant in food and rivers.{66547,66549}