产品描述:
ML-SA5 is an agonist of transient receptor potential mucolipin 1 (TRPML1).{65842} It activates whole-endolysosome TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Item No. 20425) (EC50 = 333 nM). ML-SA5 (3 µM) is cytotoxic to MeWo and M12 melanoma cells but not normal melanocytes. It induces gastric acid secretion in isolated stomach from wild-type but not TRPML1-/- mice.{65843} ML-SA5 (2 and 5 mg/kg) decreases the necrotic area and percentage of centrally nucleated fibers in the dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy.{65844}