产品描述:
Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation.{32513} Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates.{32515} It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.{32514}