产品描述:
17α-Hydroxyprogesterone (17-OHP) is a steroid and precursor in the synthesis of adrenal androgens.{54784,54785} It binds to the glucocorticoid receptor in a cell-free assay (IC50 = 82 nM for the human receptor) and induces glucocorticoid receptor transactivation in HEK293 cells (EC50 = 1.2 µM).{54785} 17-OHP (0.005-1 µM) inhibits aldosterone-induced transactivation of the mineralocorticoid receptor in cell-based assays.{54784} Serum levels of 17-OHP are increased in patients with congenital adrenal hyperplasia.{54784,54785}