产品描述:
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor with key roles in adipocyte differentiation and glucose homeostasis.{18294,14553} G3335 is a cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM).{28551} It reversibly and competitively blocks activation of PPARγ by rosiglitazone (IC50 = 8-32 µM).{28551} G3335 is active in vivo, abolishing the protective effects of rosiglitazone in experimental spinal cord injury in rats.{28550} G3335 has also been used to evaluate the role of PPARγ in neurotoxicity studies.{28549,28552}