产品描述:
GPR119, a glucose-dependent insulinotropic receptor, is a Gs protein-coupled receptor that is expressed in pancreas β-cells and intestinal L-cells.{14046} Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine and oleoyl ethanolamide increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion.{14046,18880} AS-1269574 is an agonist of GPR119 that is effective both in isolated cells and in vivo.{18583} It increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and glucose-stimulated insulin secretion in mice (100 mg/kg).{18583}