产品描述:
Flavokawain A is a chalcone that has been found in P. methysticum and has diverse biological activities.{61956,61957,61958} It activates nuclear factor erythroid 2-related factor 2 (Nrf2) and heat shock factor 1 (Hsf1; EC50s = 14.1 and 7.9 µM, respectively, in reporter assays), increases glutathione (GSH) levels, and protects against hydrogen peroxide-induced cytotoxicity in HepG2 cells.{61956} Flavokawain A (10 and 20 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels in RAW 264.7 macrophages.{61957} It induces apoptosis in T24 bladder cancer cells when used at a concentration of 12.5 µg/ml.{61958} Flavokawain A (50 mg/kg) reduces tumor growth in an EJ bladder cancer mouse xenograft model.