产品描述:
BayCysLT2 is a cysteinyl leukotriene 2 (CysLT2) receptor antagonist (IC50 = 53 nM).{65631} It selectively inhibits calcium mobilization induced by leukotriene D4 (LTD4; Item No. 20310) in HEK293 cells expressing human CysLT2 receptors over HEK293 cells expressing CysLT1 receptors when used at a concentration of 100 nM. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts.{18564} In vivo, BayCysLT2 (3 mg/kg) reduces infarct volume in a human CysLT2 receptor transgenic mouse model of myocardial ischemia and reperfusion injury induced by left anterior descending coronary artery (LAD) ligation.{65631}