产品描述:
JTC 801 is an antagonist of the nociceptin receptor (ORL1; Ki = 44.5 nM; IC50 = 94 nM) that is >100-, >100-, and >3-fold more selective for ORL1 over the related δ-, κ-, and µ-opioid receptors, respectively.{33471} It demonstrates anti-nociceptive effects in acute pain models in mice upon oral administration at 1 mg/kg.{33471}