产品描述:
SANT-2 is a Smoothened (Smo) receptor antagonist.{21771,24191} It binds to the Smo receptor (Kd = 12 nM) and inhibits binding of the Smo receptor agonist SAG-1.3 (SAG; Item No. 11914) and antagonist cyclopamine (Item No. 11321) (Kis = 7.8 and 8.4 nM, respectively). SANT-2 inhibits hedgehog signaling induced by an N-terminal fragment of sonic hedgehog (Shh) in an Shh-LIGHT2 cellular assay (IC50 = 30 nM).{21771}