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产品名称:
FTY720 . hydrochloride
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别名:
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl; Fingolimod; Gilenya
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产品描述:
Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Shown to induce autophagy and apoptosis.
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反应种属:
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宿主来源:
Synthetic analog of ISP-1, isolated from Isaria sinclairii.
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实验应用:
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靶标/特异性:
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同种型:
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产品浓度:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
307.4 . 36.5
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C.
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产地:
瑞士
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外观:
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纯度:
>98%
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Accession #:
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CAS号:
162359-56-0
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分子式:
C19H33NO2 . HCl
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溶解度:
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PubChem CID: