产品描述:
Stable synthetic cerulenin derivative. Competitive irreversible fatty acid synthase (FASN) inhibitor that acts on ketoreductase (KR), acyl carrier protein (ACP) and thioesterase (TE) domains. Used to study fatty acid synthesis in metabolic disorders and cancer. Useful agent for immunometabolism research. Anorexigenic agent, activating CPT1 to accelerate fatty acid beta-oxidation. Shown to inhibit food intake through AMPK-related pathways. Cytotoxic to many cancer cell lines. Antitumor agent shown to suppress DNA replication and induce apoptosis. Specifically blocks TLR/MYD88 signaling in neutrophils.