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产品名称:
Splitomicin
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别名:
Splitomycin; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1-Naphthalen propanoic acid
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产品描述:
Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4]. Displays higher activity in vivo than in vitro [1-4]. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5]. Shown to have diverse effects also in mammalian cells [6-10].
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同种型:
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表达系统:
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阳性对照:
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保存温度:
-20°C
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运输温度:
Ambient
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细胞定位:
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预期分子量:
198.2
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产品形式:
solid
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存储溶液:
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有效期:
Stable for at least 2 years after receipt when stored at -20°C.
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产地:
瑞士
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纯度:
>98% (NMR)
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Accession #:
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CAS号:
5690-03-9
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分子式:
C13H10O2
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溶解度:
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PubChem CID: