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LY294002 (hydrochloride)
品牌: Cayman
产品货号: 39171-25 mg
规格: 25 mg

报价:
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数量: - +
产品详情
* 以下信息仅供参考,详情请以原厂网站为准
  • 产品名称:
    LY294002 (hydrochloride)
  • 别名:
  • 产品描述:
    LY294002 is a multi-kinase inhibitor.{38012} It inhibits casein kinase 2 (CK2; IC50 = 0.098 µM), the PI3K subunits p110α, p110β, p110δ, and p110γ (IC50s = 0.497, 0.554, 0.331, and 3.8 µM, respectively), and DNA protein kinase (DNA-PK; IC50 = 6 µM), among other kinases, as well as inhibits CK1, GSK3α, and GSK3β by greater than 40% at 10 µM.{38012,65964,17331} LY294002 (12.5, 25, and 50 µM) reduces viability of SGC-7901 human gastric cancer cells.{65965} It also induces apoptosis and autophagy in SGC-7901 cells when used at a concentration of 50 µM. LY294002 (2 ng/ml/kg) reduces tumor volume in DLD-1 and LoVo mouse xenograft models.{65966} It also reduces aging-induced increases in the number of aging human vascular smooth muscle cells (VSMCs) positive for senescence-associated β-galactosidase (SA-β-gal) when used at a concentration of 20 µM in the 5th to 15th generations.{65967}
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  • 阳性对照:
  • 保存温度:
    -20
  • 运输温度:
    -20
  • 细胞定位:
  • 预期分子量:
    343.8
  • 产品形式:
    A solid
  • 存储溶液:
  • 有效期:
    1460
  • 产地:
    美国
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  • 纯度:
    ≥98%
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  • CAS号:
    934389-88-5
  • 分子式:
    C19H17NO3 • HCl
  • 溶解度:
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